سنتز پروتئین شیمیایی Chemical Protein Synthesis

فهرست مطالب: Preface . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . ix 1 Sulfated Glycoprotein Synthesis. . . . . . . . . . . . . 1 2 Total Chemical Synthesis of a SARS-CoV-2 Miniprotein Inhibitor LCB1 . . . . . . 19 3 Serine/Threonine Ligation and Cysteine/Penicillamine Ligation . . . . . . . . . . . . . 33 4 Continuous-Flow Synthesis of N-Methylated Peptides via Generation of an Acyl N-Methylimidazolium Cation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 5 Covalent Reactive Peptides to Block Protein–Protein Interactions and Inhibit Microbe–Host Interaction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 6 Ynamide-Mediated Synthetic Approach to Thioamide-Substituted Peptides . . . . . . . . . 69 7 Improved Handling of Peptide Segments Using Side Chain-Based “Helping Hand” Solubilizing Tools . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 8 General Solution to the Preparation of β-Thiolated/Selenolated Amino Acids Via Visible Light Catalyzed Asymmetric Giese Reaction . . . . . . . . . 109 9 Side-Chain Anchoring Strategies for the Synthesis of Peptide Thioesters and Selenoesters . . . . . . . . . . . . 125 10 Preparation of Site-Specific Succinylated Histone Mimics to Investigate Its Impact on Nucleosome Dynamics. . . . . . . . . . 141 11 Protein Synthesis via Activated Cysteine-Directed Protein Ligation . . . . . . . . . . . 159 12 Sulfonium-Tethered Peptide . . . . . . . . 169 13 PAL-Mediated Ligation for Protein and Cell-Surface Modification. . . . . . . . . . . . 177 14 Development of a Glycoform Library-based Strategy to Decipher the Role of Protein Glycosylation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195 15 A Selenium-based Cysteine Surrogate for Protein Chemical Synthesis . . . . . . . . . 213 16 Removable Backbone Modification (RBM) Strategy for the Chemical Synthesis of Hydrophobic Peptides/Proteins. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241 Index . . . . . . . . . . . . . . . . . . 257    مشخصات فایل
عنوان (Title):	Chemical Protein Synthesis
نام فایل (File name):	896-www.GeneProtocols.ir-Chemical Protein Synthesis-Humana (2022).pdf
عنوان فارسی (Title in Persian):	سنتز پروتئین شیمیایی
ایجاد کننده:	Xuechen Li (editor)
زبان (Language):	انگلیسی English
سال انتشار:	2022
شابک ISBN:	1071624881, 9781071624883
نوع سند (Doc. type):	کتاب
فرمت (File extention):	PDF
حجم فایل (File size):	9.12 مگابایت
تعداد صفحات (Book length in pages):	258

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