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فهرست مطالب:
Preface ix
1 Breeding a Perfect Society 1
Beginnings: Davenport and eugenics in the United States . . . IQ
and involuntary sterilization . . . Genetics against eugenics . . .
Exporting sterilization . . . The Watson scandal . . . Establishing
human genetics . . . Davenport’s dreams today
2 Molecular Diseases, Elusive Treatments 23
The molecularization of biology . . . Molecular diseases . . . But
no molecular medicine . . . Dreams of editing genes . . . Followed
by stunning failure . . . Recombinant DNA made no difference . . .
Gene editing BC (before CRISPR)
3 What Good Was the Human Genome Project? 41
The sequence revealed . . . Common diseases and common variants
. . . Medical irrelevance of the sequence . . . Critiques of the HGP,
past and present . . . Evolution and architecture of the genome . . .
Evolutionary contingency
4 The CRISPR Revolution 59
The CRISPR structure emerges . . . Its function is decoded . . . The
mechanism of immunity . . . Onward to Gene editing . . . The
delivery problem . . . Ubiquitous CRISPR
5 Inevitable Eugenics? 77
Eugenics in the news . . . What is eugenics? . . . Defining eugenics
. . . A working definition . . . Inescapable eugenics? . . . Matters of
ethics
6 The Elimination of Genetic Diseases 95
The long reach of Huntington’s disease . . . The He Jiankui affair
. . . The ethics of human germline intervention . . . The limits of
current science . . . Gene specificity and Lenin’s brain . . . A policy
proposal . . . Proceed with caution . . . Liberal and moderate
eugenics
7 Designer Baby Delusions 117
Why not genetic enhancement? . . . The normal and the enhanced
. . . Liberal eugenics and genetic enhancement . . . Rationality of
genetic enhancement . . . Planned human obsolescence . . . Where is
the science? The case of intelligence . . . Genomics and IQ . . .
What about physical traits? . . . Genetic reductionism . . .
Contextual developmental construction . . . What is perfection?
8 A CRISPR Future 149
Editing the human germline . . . Gene drives . . . The ethics of
promoting extinction . . . Biosecurity . . . CRISPR without the hype
Notes 165
Acknowledgments 177
References 179
Index 195
About the Author 205
مشخصات فایل
|
| عنوان (Title): |
Cut-and-Paste Genetics: A CRISPR Revolution |
| نام فایل (File name): |
724-www.GeneProtocols.ir-Cut-and-Paste Genetics_ A CRISPR Revolution-Rowman & Littlefield (2021).pdf |
| عنوان فارسی (Title in Persian): |
ژنتیک برش و اتصال- انقلاب کریسپر |
| ایجاد کننده: |
Sahotra Sarkar |
| زبان (Language): |
انگلیسی English |
| سال انتشار: |
2021 |
| شابک ISBN: |
1786614375,9781786614377 |
| نوع سند (Doc. type): |
کتاب |
| فرمت (File extention): |
PDF |
| حجم فایل (File size): |
2.64 مگابایت |
| تعداد صفحات (Book length in pages): |
225 |
پس از پرداخت، دانلود فایل آغاز می شود
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