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قابل دانلود از شنبه, ۲۸ مرداد ۱۴۰۲
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فهرست مطالب: Preface................ . . . . . vContributors................. xi PART I OVERVIEW 1 Updates on Cardiac Gene Therapy Research and Methods: Overview of Cardiac Gene Therapy............ 3 PART II GENE SUPPRESSION, EDITING, AND REPROGRAMMING 2 Tough Decoy-Mediated Cardiac Gene Suppression...... . 13 3 Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes Using miRcombo....... . . . 31 4 CRISPR/Cas9 Gene Editing of RYR2 in Human iPSC-Derived Cardiomyocytes to Probe Ca2+ Signaling Aberrancies of CPVT Arrhythmogenesis.......... . . . . . . 41 5 Enhancing Cardiomyocyte Transcription Using In Vivo CRISPR/Cas9 Systems............ . . 53 6 AAV-Mediated Somatic Gene Editing for Cardiac and Skeletal Muscle in a Large Animal Model........... . 63 PART III CARDIAC GENE THERAPY VECTORS AND PROMOTORS 7 Optimization of Synthesis of Modified mRNA....... . . . . . 77 8 Design and Production of Heart Chamber-Specific AAV9 Vectors.. . . . . 89 9 Generation of Atrial-Specific Construct Using Sarcolipin Promoter-Associated CRM4 Enhancer........ . . . . 115 PART IV CARDIAC GENE DELIVERY METHODS 10 Cardiac Targeted Adeno-Associated Virus Injection in Rats.... . . 135 11 Cardiac Gene Delivery in Large Animal Models: Antegrade Techniques............. . . 147 12 Locked Nucleic Acid AntimiR Therapy for the Heart.....159 13 Cardiac Gene Delivery in Large Animal Models: Selective Retrograde Venous Injection..............171 14 Endocardial Gene Delivery Using NOGA Catheter System.... . . 179 15 Surgical Methods for Cardiac Gene Delivery in Large Animals...189 16 Atrial Gene Painting in Large Animal Model of Atrial Fibrillation... . . . . 205 17 Stent-Based Gene Delivery for Coronary Disease...... . . . 217 18 Selective Anti-AAV Antibody Depletion by Hemapheresis and Immunoadsorption............ . 235 19 Ex Vivo Delivery of Viral Vectors by Organ Perfusion for Cardiac Transplantation Gene Therapy........ . 249 PART V PULMONARY HYPERTENSION 20 Intra-Airway Gene Delivery for Pulmonary Hypertension in Rodent Models............. . . . . . . 263 21 Endobronchial Gene Delivery for Pulmonary Hypertension in a Large Animal Model............ 279 PART VI PATIENT SCREENING AND MEASURING THE EFFICACY OF CARDIAC GENE THERAPY 22 Cell-Based Determination of Neutralizing Antibodies Against Adeno-Associated Virus in Cardiac Gene Therapy...... . . 293 23 Left Ventricular Pressure Volume Assessment Using Carotid Artery Access in the Rat............ . 305 24 Assessing the Effect of Cardiac Gene Therapy Using Catheter-Based Pressure–Volume Measurement in Large Animals...... . . . 313 25 ELISpot Assay for Gene Therapy in Large Animal Studies.... . . . 323 26 Assessing Recombinant AAV Shedding After Cardiac Gene Therapy.. . . 333 Index................ . . . . . . 345 |
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فهرست به فارسی (ترجمه ماشینی): پیشگفتار................. . . . . v |
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مشخصات فایل |
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| عنوان (Title): | Cardiac Gene Therapy_ Methods and Protocols |
| نام فایل (File name): | 1176-www.GeneProtocols.ir-Cardiac Gene Therapy_ Methods and Protocols-Humana Press (2022).pdf |
| عنوان فارسی (Title in Persian): |
ژن درمانی قلبی - روشها و پروتکل ها |
| ایجاد کننده: | Kiyotake Ishikawa |
| زبان (Language): | انگلیسی English |
| سال انتشار: | 2022 |
| شابک ISBN: | 9781071627068 |
| نوع سند (Doc. type): | کتاب |
| فرمت (File extention): | |
| حجم فایل (File size): | 14.7 مگابایت |
| تعداد صفحات (Book length in pages): | 341 |
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